Polyelectrolyte nanocontainers: controlled binding and release of indomethacin

Mirgorodskaya, A. B., Kushnazarova, R. A., Nikitina, A. V., Semina, I. I., Nizameev, I. R., Kadirov, M. K., Khutoryanskiy, V. V. ORCID: https://orcid.org/0000-0002-7221-2630, Zakharova, L. Y. and Sinyashin, O. G. (2018) Polyelectrolyte nanocontainers: controlled binding and release of indomethacin. Journal of Molecular Liquids, 272. pp. 982-989. ISSN 0167-7322 doi: 10.1016/j.molliq.2018.10.115

Abstract/Summary

Herein, polyelectrolyte capsules containing anti-inflammatory drug indomethacin were formed using layer-by-layer strategy, which involves alternative deposition of oppositely charged polyelectrolytes, such as poly(acrylic acid) and poly(ethyleneimine) (or chitosan) onto the drug substrate. Two variants of encapsulation have been implemented: direct deposition of polyelectrolytes onto indomethacin dispersed in water at рН 6, and preliminary formation of soft matrix by solubilization of indomethacin in micellar solutions of cationic surfactants. The inclusion of indomethacin into nanosized polyelectrolyte capsules (hydrodynamic diameter of three- and five-layer capsules is 90–180 nm) has given a new form of indomethacin with the drug content of 0.20–0.25%, which exceeds its limiting solubility in water nearly by the factor of 40. The choice of materials and procedures used for preparation of capsules, as well as the number of polyelectrolyte layers that form shell has provided the control of the drug release from capsule and resulted in the design of pharmaceutical dosage forms with long-lasting effect.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/80120
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
Publisher	Elsevier
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