High-pressure structural studies of the pharmaceutical, chlorothiazide

Oswald, I. D. H., Lennie, A. R., Pulham, C. R. and Shankland, K. ORCID: https://orcid.org/0000-0001-6566-0155 (2010) High-pressure structural studies of the pharmaceutical, chlorothiazide. Crystengcomm, 12 (9). pp. 2533-2540. ISSN 1466-8033 doi: 10.1039/c001355b

Abstract/Summary

The pharmaceutical material chlorothiazide (6-chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide) has been studied under high-pressure conditions using single-crystal and powder X-ray diffraction. An isosymmetric phase transition to a second polymorph occurs at 4.4 GPa. An analysis of the structural changes that occur during this phase transition has been performed.