Systematic review and meta-analysis: anxiety and depressive disorders in offspring of parents with anxiety disorders

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Lawrence, P. J., Murayama, K. and Creswell, C. (2019) Systematic review and meta-analysis: anxiety and depressive disorders in offspring of parents with anxiety disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 58 (1). pp. 46-60. ISSN 0890-8567 doi: 10.1016/j.jaac.2018.07.898

Abstract/Summary

Objective: We conducted meta-analyses to assess risk of anxiety disorders among offspring of parents with anxiety disorders and to establish whether there is evidence of specificity of risk for anxiety disorders as opposed to depression in offspring, and whether particular parent anxiety disorders confer risks for particular child anxiety disorders. We also examined whether risk was moderated by offspring age, gender, temperament and the presence of depressive disorders in parents. Method: We searched PsycINFO, PubMed and Web of Science in June, 2016 and July, 2017 (PROSPERO CRD42016048814). Study inclusion criteria: published in peer-reviewed journals; contained at least one group of parents with anxiety disorders and at least one comparison group of parents who did not have anxiety disorders; reported rates of anxiety disorders in offspring, and used validated diagnostic tools to ascertain diagnoses. We used random and mixed-effects models and evaluated study quality. Results: We included 25 studies (7285 offspring). Where parents had an anxiety disorder, offspring were significantly more likely to have anxiety (RR: 1.76, 95% CI = 1.58-1.96) and depressive disorders (RR: 1.31, 95% CI = 1.13-1.52) than offspring of parents without anxiety disorders. Parent Panic Disorder and Generalized Anxiety Disorder appeared to confer particular risk. Risk was greater for offspring anxiety than depressive disorders (RR: 2.50, 95% CI = 1.50-4.16), and specifically for offspring Generalized Anxiety Disorder, Separation Anxiety Disorder and Specific Phobia, but there was no evidence that children of parents with particular anxiety disorders were at increased risk for the same particular anxiety disorders. Moderation analyses were possible only for offspring age, gender and parental depressive disorder; none were significant. Conclusions: Parent anxiety disorders pose specific risks of anxiety disorders to offspring. However, there is limited support for transmission of the same particular anxiety disorder. These results support the potential for targeted prevention of anxiety disorders.

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Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/78608
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Psychology and Clinical Language Sciences > Anxiety and Depression in Young People (AnDY) Life Sciences > School of Psychology and Clinical Language Sciences > Department of Psychology Life Sciences > School of Psychology and Clinical Language Sciences > Psychopathology and Affective Neuroscience
Publisher	Elsevier
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Funders:	National Institute for Health Research	The sponsoring bodies who contributed funding for the creation of this item. Example: NERC Example: The Royal Society of Chemistry A pick list of funders may appear as you type in the funder's name in full or as an acronym. Select a correct match to complete the field or type in a new entry in full. For new entries, the full name is preferred.
Projects:	Professorship - Treatments for childhood anxiety disorders: Improving patient access and clinical effectiveness Funded by: National Institute for Health Research (RP_2014-04-018 - £1,267,210) Local Lead (PI): Catharine Creswell 1 October 2014 - 30 September 2019	Click Add to select your project (received at Reading) from an autocomplete list.

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Date Deposited:	22 Aug 2018 10:56	Date item deposited into CentAUR
Last Modified:	31 Jan 2025 02:36	Date item last modified

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