Combining C-H functionalisation and flow photochemical heterocyclic metamorphosis (FP-HM) for the synthesis of benzo[1,3]oxazepines

Babra, J. S., Russell, A. T., Smith, C. D. ORCID: https://orcid.org/0000-0002-5911-5836 and Zhang, Y. (2018) Combining C-H functionalisation and flow photochemical heterocyclic metamorphosis (FP-HM) for the synthesis of benzo[1,3]oxazepines. Tetrahedron, 74 (38). pp. 5351-5357. ISSN 0040-4020 doi: 10.1016/j.tet.2018.05.066

Abstract/Summary

C-H Activation/functionalisation and Flow Photochemical Heterocyclic Metamorphosis (FP-HM) have been combined to synthesize a library of benzo[1,3]oxazepines, a rarely described heterocyclic family. This combined protocol allows a range of arylated products to be made from simple starting materials, and the cheap flow photochemical system has proven effective for rapid synthesis of gram-quantities of benzo[1,3]oxazepines.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/77396
Identification Number/DOI	10.1016/j.tet.2018.05.066
Refereed	Yes
Divisions	Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) > Mass Spectrometry (CAF) Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) > NMR (CAF)
Uncontrolled Keywords	Flow; Photochemistry; Heterocyclic metamorphosis; Quinoline N-oxide; Benzo[1,3]oxazepine
Publisher	Elsevier
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