Formulation of carbopol®/Poly(2-ethyl-2-oxazoline)s mucoadhesive tablets for buccal delivery of hydrocortisone

Ruiz-Rubio, L., Alonso, M. L., Pérez-Álvarez, L., Alonso, R. M., Vilas, J. L. and Khutoryanskiy, V. ORCID: https://orcid.org/0000-0002-7221-2630 (2018) Formulation of carbopol®/Poly(2-ethyl-2-oxazoline)s mucoadhesive tablets for buccal delivery of hydrocortisone. Polymers, 10 (2). 175. ISSN 2073-4360 doi: 10.3390/polym10020175

Abstract/Summary

Poly(2-ethyl-2-oxazoline) has become an excellent alternative to the use of poly(ethylene glycol) in pharmaceutical formulations due to its valuable physicochemical and biological properties. This work presents a formulation of poorly-water soluble drug, hydrocortisone, using interpolymer complexes and physical blends of poly(2-ethyl-2-oxazoline)s and two Carbopols® (Carbopol 974 and Carbopol 971) for oromucosal administration. The swelling, hydrocortisone release and mucoadhesive properties of a series of tablet formulations obtained by combination of different Carbopols with poly(2-ethyl-2-oxazoline)s of different molecular weights have been evaluated in vitro.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/75575
Identification Number/DOI	10.3390/polym10020175
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
Publisher	MDPI
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