Feasibility of polymer-drug conjugates for non-cancer applications

Natfji, A. A., Osborn, H. M. I. ORCID: https://orcid.org/0000-0002-0683-0457 and Greco, F. (2017) Feasibility of polymer-drug conjugates for non-cancer applications. Current Opinion in Colloid & Interface Science, 31. pp. 51-66. ISSN 1359-0294 doi: 10.1016/j.cocis.2017.07.004

Abstract/Summary

Polymer-drug conjugates have been intensely studied in the context of improving cancer chemotherapy and yet the only polymer-drug conjugate on the market (MovantikÒ) has a different therapeutic application (relieving opioid-induced constipation). In parallel, a number of studies have recently been published proposing the use of this approach for treating diseases other than cancer. In this commentary, we analyse the many and very diverse applications that have been proposed for polymer-drug conjugates (ranging from inflammation, to cardiovascular diseases) and the rationales underpinning them. We also highlight key design features to be considered when applying polymer-drug conjugates to these new therapeutic areas.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/72706
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Medicinal Chemistry Research Group Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
Publisher	Elsevier
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