LRRK2 at the interface of autophagosomes, endosomes and lysosomes

Roosen, D. A. and Cookson, M. R. (2016) LRRK2 at the interface of autophagosomes, endosomes and lysosomes. Molecular Neurodegeneration, 11 (1). 73. ISSN 1750-1326 doi: 10.1186/s13024-016-0140-1

Abstract/Summary

Over the past 20 years, substantial progress has been made in identifying the underlying genetics of Parkinson’s disease (PD). Of the known genes, LRRK2 is a major genetic contributor to PD. However, the exact function of LRRK2 remains to be elucidated. In this review, we discuss how familial forms of PD have led us to hypothesize that alterations in endomembrane trafficking play a role in the pathobiology of PD. We will discuss the major observations that have been made to elucidate the role of LRRK2 in particular, including LRRK2 animal models and high-throughput proteomics approaches. Taken together, these studies strongly support a role of LRRK2 in vesicular dynamics. We also propose that targeting these pathways may not only be beneficial for developing therapeutics for LRRK2-driven PD, but also for other familial and sporadic cases.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/70164
Identification Number/DOI	10.1186/s13024-016-0140-1
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy
Publisher	Bio Med Central
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