Lipid-coated polymeric nanoparticles for cancer drug delivery

Krishnamurthy, S., Vaiyapuri, R., Zhang, L. and Chan, J. M. (2015) Lipid-coated polymeric nanoparticles for cancer drug delivery. Biomaterials Science, 3 (7). pp. 923-936. ISSN 2047-4830 doi: 10.1039/C4BM00427B

Abstract/Summary

Polymeric nanoparticles and liposomes have been the platform of choice for nanoparticle-based cancer drug delivery applications over the past decade, but extensive research has revealed their limitations as drug delivery carriers. A hybrid class of nanoparticles, aimed at combining the advantages of both polymeric nanoparticles and liposomes, has received attention in recent years. These core/shell type nanoparticles, frequently referred to as lipid–polymer hybrid nanoparticles (LPNs), possess several characteristics that make them highly suitable for drug delivery. This review introduces the formulation methods used to synthesize LPNs and discusses the strategies used to treat cancer, such as by targeting the tumor microenvironment or vasculature. Finally, it discusses the challenges that must be overcome to realize the full potential of LPNs in the clinic.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/69622
Identification Number/DOI	10.1039/C4BM00427B
Refereed	Yes
Divisions	University of Reading Malaysia
Publisher	Royal Society of Chemistry
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