A de novo virus-like topology for synthetic virions

Noble, J. E., De Santis, E. ., Ravi, J., Lamarre, B., Castelletto, V., Ray, S. and Ryadnov, M. G. (2016) A de novo virus-like topology for synthetic virions. Journal of the American Chemical Society, 138 (37). pp. 12202-12210. ISSN 0002-7863 doi: 10.1021/jacs.6b05751

Abstract/Summary

A de novo ultra-small topology of viral assembly is reported. The design is a tri-faceted coiled-coil peptide helix, which self-assembles into monodisperse, anionic virions able to encapsulate and transfer both RNA and DNA into human cells. Unlike existing artificial systems, the virions share the same physical characteristics of viruses being anionic, non-aggregating, abundant, hollow and uniform in size, while effectively mediating gene silencing and transgene expression. These are the smallest virions reported to date with the ability to adapt and transfer small and large nucleic acids thus offering a promising solution for engineering bespoke artificial viruses with desired functions.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/67291
Identification Number/DOI	10.1021/jacs.6b05751
Refereed	Yes
Divisions	Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Publisher	American Chemical Society
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