Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres

Omairi, S., Matsakas, A., Degens, H., Kretz, O., Hansson, K.-A., Våvang Solbrå, A., Bruusgaard, J., Joch, B., Sartori, R., Giallourou, N., Mitchell, R., Collins-Hooper, H., Foster, K., Pasternack, A., Ritvos, O., Sandri, M., Narkar, V., Swann, J., Huber, T. and Patel, K. (2016) Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres. eLIFE, 5. e16940. ISSN 2050-084X doi: 10.7554/eLife.16940

Abstract/Summary

A central tenet of skeletal muscle biology is the existence of an inverse relationship between the oxidative fibre capacity and its size. However robustness of this relationship is unknown. We show that superimposition of Estrogen Related Receptor Gamma (Errγ) on the Myostatin (Mtn) mouse null background (Mtn-/-/ErrγTg/+) results in hypertrophic muscle with a high oxidative capacity thus violating the inverse relationship between fibre size and oxidative capacity. We also examined the canonical view that oxidative muscle phenotype positively correlate with Satellite cell number, the resident stem cells of skeletal muscle. Surprisingly, hypertrophic fibres from Mtn-/-/ErrγTg/+ mouse showed satellite cell deficit which unexpectedly did not affect muscle regeneration. These observations 1) challenge the concept of a constraint between fibre size and oxidative capacity and 2) indicate the important role of the microcirculation in the regenerative capacity of a muscle even when satellite cell numbers are reduced.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/66190
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Biological Sciences > Biomedical Sciences
Publisher	eLife Sciences Publications
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