Cupreines and cupreidines: an established class of bifunctional cinchona organocatalysts

Bryant, L. A., Fanelli, R. and Cobb, A. J. A. (2016) Cupreines and cupreidines: an established class of bifunctional cinchona organocatalysts. Beilstein Journal of Organic Chemistry, 12. pp. 429-443. ISSN 1860-5397 doi: 10.3762/bjoc.12.46

Abstract/Summary

Cinchona alkaloids with a free 6'-OH functionality are being increasingly used within asymmetric organocatalysis. This fascinating class of bifunctional catalyst offers a genuine alternative to the more commonly used thiourea systems and because of the different spacing between the functional groups, can control enantioselectivity where other organocatalysts have failed. In the main, this review covers the highlights from the last five years and attempts to show the diversity of reactions that these systems can control. It is hoped that chemists developing asymmetric methodologies will see the value in adding these easily accessible, but underused organocatalysts to their screens.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/61841
Identification Number/DOI	10.3762/bjoc.12.46
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Medicinal Chemistry Research Group
Publisher	Beilstein-Institut
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