A peptide hydrogel derived from a fragment of human cardiac troponin C

Leon-Rodriguez, L. M. D., Kamalov, M., Hemar, Y., Mitra, A. K., Castelletto, V., Hermida-Merino, D., Hamley, I. W. ORCID: https://orcid.org/0000-0002-4549-0926 and Brimble, M. A. (2016) A peptide hydrogel derived from a fragment of human cardiac troponin C. Chemical Communications, 52 (21). pp. 4056-4059. ISSN 1359-7345 doi: 10.1039/c6cc00209a

Abstract/Summary

The human cardiac troponin C peptide fragment H-V9EQLTEEQKN EFKAAFDIFVLGA31-OH, which covers helix-A in the native protein, self-assembles into b-sheet fibrils in solution. These fibrils further entangle to give a hydrogel. This peptide may therefore serve as a template for development of novel biomaterials.