Platelet signaling: a complex interplay between inhibitory and activatory networks

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Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Unsworth, A. J. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2016) Platelet signaling: a complex interplay between inhibitory and activatory networks. Journal of Thrombosis and Haemostasis, 14 (5). pp. 918-930. ISSN 1538-7933 doi: 10.1111/jth.13302

Abstract/Summary

The role of platelets in hemostasis and thrombosis is dependent on a complex balance of activatory and inhibitory signaling pathways. Inhibitory signals released from the healthy vasculature suppress platelet activation in the absence of platelet receptor agonists. Activatory signals present at a site of injury initiate platelet activation and thrombus formation; subsequently, endogenous negative signaling regulators dampen activatory signals to control thrombus growth. Understanding the complex interplay between activatory and inhibitory signaling networks is an emerging challenge in the study of platelet biology and necessitates a systematic approach to utilize experimental data effectively. In this review, we will explore the key points of platelet regulation and signaling that maintain platelets in a resting state, mediate activation to elicit thrombus formation or provide negative feedback. Platelet signaling will be described in terms of key signaling molecules that are common to the pathways activated by platelet agonists and can be described as regulatory nodes for both positive and negative regulators. This article is protected by copyright. All rights reserved.

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Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/57693
Identification Number/DOI	10.1111/jth.13302
Refereed	Yes
Divisions	Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR) Life Sciences > School of Biological Sciences > Biomedical Sciences
Uncontrolled Keywords	Blood; Platelets; Hemostasis; Platelet Activation; Review; Thrombosis; Signalling; Haemostasis
Publisher	Wiley
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Funded Project

Funders:	British Heart Foundation	The sponsoring bodies who contributed funding for the creation of this item. Example: NERC Example: The Royal Society of Chemistry A pick list of funders may appear as you type in the funder's name in full or as an acronym. Select a correct match to complete the field or type in a new entry in full. For new entries, the full name is preferred.
Projects:	The physiological importance and integration of receptor-mediated inhibitory mechanisms in platelets Funded by: British Heart Foundation (RG/09/011/28094 - £937,084) Local Lead (PI): Jon Gibbins 1 September 2010 - 31 August 2015 The physiological importance and integration of receptor-mediated inhibitory mechanisms in platelets in health and disease Funded by: British Heart Foundation (RG/15/2/31224 - £1,426,158) Local Lead (PI): Jon Gibbins 1 September 2015 - 31 August 2020	Click Add to select your project (received at Reading) from an autocomplete list.

Deposit Details

Date Deposited:	16 Mar 2016 09:19	Date item deposited into CentAUR
Last Modified:	09 Jun 2024 03:28	Date item last modified

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