Impact of chemical structure of flavanol monomers and condensed tannins on in vitro anthelmintic activity against bovine nematodes

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Desrues, O., Fryganas, C., Ropiak, H. M., Mueller-Harvey, I., Enemark, H. L. and Thamsborg, S. M. (2016) Impact of chemical structure of flavanol monomers and condensed tannins on in vitro anthelmintic activity against bovine nematodes. Parasitology, 143 (4). pp. 444-454. ISSN 0031-1820 doi: 10.1017/S0031182015001912

Abstract/Summary

Plants containing condensed tannins (CT) may have potential to control gastrointestinal nematodes (GIN) of cattle. The aim was to investigate the anthelmintic activities of four flavan-3-ols, two galloyl derivatives and 14 purified CT fractions, and to define which structural features of CT determine the anti-parasitic effects against the main cattle nematodes. We used in vitro tests targeting L1 larvae (feeding inhibition assay) and adults (motility assay) of Ostertagia ostertagi and Cooperia oncophora. In the larval feeding inhibition assay, O. ostertagi L1 were significantly more susceptible to all CT fractions than C. oncophora L1. The mean degree of polymerization of CT (i.e. average size) was the most important structural parameter: large CT reduced larval feeding more than small CT. The flavan-3-ols of prodelphinidin (PD)-type tannins had a stronger negative influence on parasite activity than the stereochemistry, i.e. cis- vs trans-configurations, or the presence of a gallate group. In contrast, for C. oncophora high reductions in the motility of larvae and adult worms were strongly related with a higher percentage of PDs within the CT fractions while there was no effect of size. Overall, the size and the percentage of PDs within CT seemed to be the most important parameters that influence anti-parasitic activity.

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Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/48735
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Agriculture, Policy and Development > Department of Animal Sciences > Animal, Dairy and Food Chain Sciences (ADFCS)- DO NOT USE
Publisher	Cambridge University Press
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Funders:	European Commission	The sponsoring bodies who contributed funding for the creation of this item. Example: NERC Example: The Royal Society of Chemistry A pick list of funders may appear as you type in the funder's name in full or as an acronym. Select a correct match to complete the field or type in a new entry in full. For new entries, the full name is preferred.
Projects:	Optimising plant polyphenols in LEGUMES for ruminant nutrition PLUS health PLUS environmental sustainability (LegumePlus) Funded by: European Commission (289377 - £816,894) Local Lead (PI): Irene Mueller-Harvey 1 January 2012 - 31 December 2015	Click Add to select your project (received at Reading) from an autocomplete list.

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Date Deposited:	04 Jan 2016 16:27	Date item deposited into CentAUR
Last Modified:	23 Jun 2024 02:19	Date item last modified

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