SUMOylation: novel neuroprotective approach for Alzheimer's disease?

Hoppe, J. B., Salbego, C. G. and Cimarosti, H. (2015) SUMOylation: novel neuroprotective approach for Alzheimer's disease? Aging and disease, 6 (5). pp. 322-30. ISSN 2152-5250 doi: 10.14336/AD.2014.1205

Abstract/Summary

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized in the brain by the formation of amyloid-beta (Aβ)-containing plaques and neurofibrillary tangles containing the microtubule-associated protein tau. Neuroinflammation is another feature of AD and astrocytes are receiving increasing attention as key contributors. Although some progress has been made, the molecular mechanisms underlying the pathophysiology of AD remain unclear. Interestingly, some of the main proteins involved in AD, including amyloid precursor protein (APP) and tau, have recently been shown to be SUMOylated. The post-translational modification by SUMO (small ubiquitin-like modifier) has been shown to regulate APP and tau and may modulate other proteins implicated in AD. Here we present an overview of recent studies suggesting that protein SUMOylation might be involved in the underlying pathogenic mechanisms of AD and discuss how this could be exploited for therapeutic intervention.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/46600
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
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