Elucidating the structure of chiral molecules by using amplified vibrational circular dichroism: from theory to experimental realization

Domingos, S. R., Hartl, F. ORCID: https://orcid.org/0000-0002-7013-5360, Buma, W. J. and Woutersen, S. (2015) Elucidating the structure of chiral molecules by using amplified vibrational circular dichroism: from theory to experimental realization. ChemPhysChem, 16 (16). pp. 3363-3373. ISSN 1439-7641 doi: 10.1002/cphc.201500551

Abstract/Summary

Recent experimental observations of enhanced vibrational circular dichroism (VCD) in molecular systems with low-lying electronically excited states suggest interesting new applications of VCD spectroscopy. The theory describing VCD enhancement through vibronic coupling schemes was derived by Nafie in 1983, but only recently experimental evidence of VCD amplification has demonstrated the extent to which this effect can be exploited as a structure elucidation tool to probe local structure. In this Concept paper, we give an overview of the physics behind vibrational circular dichroism, in particular the equations governing the VCD amplification effect, and review the latest experimental developments with a prospective view on the application of amplified VCD to locally probe biomolecular structure.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/46520
Identification Number/DOI	10.1002/cphc.201500551
Refereed	Yes
Divisions	Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Publisher	Wiley
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