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Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2.

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Hughes, C. E. orcid id iconORCID: https://orcid.org/0000-0002-9790-5820, Auger, J. M., McGlade, J., Eble, J. A., Pearce, A. C. and Watson, S. P. (2008) Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2. Journal of thrombosis and haemostasis : JTH, 6 (12). pp. 2152-9. ISSN 1538-7836

Abstract/Summary

The results demonstrate that Gads plays a key role in linking the adapter LAT to SLP-76 in response to weak activation of GPVI and CLEC-2 whereas LAT is required for full activation over a wider range of agonist concentrations. These results reveal the presence of a Gads-independent pathway of platelet activation downstream of LAT.

Item Type Article
URI https://reading-clone.eprints-hosting.org/id/eprint/44581
Refereed Yes
Divisions Life Sciences > School of Biological Sciences > Biomedical Sciences
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