Combination therapy: opportunities and challenges for polymer-drug conjugates as anticancer nanomedicines.

Greco, F. and Vicent, M. (2009) Combination therapy: opportunities and challenges for polymer-drug conjugates as anticancer nanomedicines. Advanced Drug Delivery Reviews, 61 (13). pp. 1203-1213. ISSN 0169-409X doi: 10.1016/j.addr.2009.05.006

Abstract/Summary

The discovery of new molecular targets and the subsequent development of novel anticancer agents are opening new possibilities for drug combination therapy as anticancer treatment. Polymer-drug conjugates are well established for the delivery of a single therapeutic agent, but only in very recent years their use has been extended to the delivery of multi-agent therapy. These early studies revealed the therapeutic potential of this application but raised new challenges (namely, drug loading and drugs ratio, characterisation, and development of suitable carriers) that need to be addressed for a successful optimisation of the system towards clinical applications.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/4406
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
Uncontrolled Keywords	Polymer-conjugate; Polymer therapeutics; Nanomedicine; Targeted drug delivery; Combination therapy; Cancer
Publisher	Elsevier Science BV
Download/View statistics	View download statistics for this item