New furoquinoline alkaloid and flavanone glycoside derivatives from the leaves of Oricia suaveolens and Oricia renieri (Rutaceae)

Nouga, A. B., Ndom, J. C., Mpondo, E. M., Nyobe, J. C. N., Njoya, A., Meva’a, L. M., Cranwell, P. ORCID: https://orcid.org/0000-0001-7156-5576, Howell, J. A. S., Harwood, L. ORCID: https://orcid.org/0000-0002-8442-7380 and Wansi, J. D. (2016) New furoquinoline alkaloid and flavanone glycoside derivatives from the leaves of Oricia suaveolens and Oricia renieri (Rutaceae). Natural Product Research, 30 (3). pp. 305-310. ISSN 1478-6419 doi: 10.1080/14786419.2015.1057727

Abstract/Summary

Fractionation of the methanol extract of the leaves of Oricia renieri and Oricia suaveolens (Rutaceae) led to the isolation of 13 compounds including the hitherto unknown furoquinoline alkaloid named 6,7-methylenedioxy-5-hydroxy-8-methoxydictamnine (1) and a flavanone glycoside named 5-hydroxy-40-methoxy-7-O-[a-Lrhamnopyranosyl(1000→500)-b-D-apiofuranosyl]-flavanoside (2), together with 11 known compounds (3–13). The structures of the compounds were determined by comprehensive analyses of their 1D and 2D NMR, mass spectral data and comparison. All compounds isolated were examined for their activity against human carcinoma cell lines. The alkaloids 1, 5, 12, 13 and the phenolic 2, 8, 11 tested compounds exhibited non-selective moderate cytotoxic activity with IC50 8.7–15.9mM whereas compounds 3, 4, 6, 7, 9 and 10 showed low activity.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/43353
Item Type	Article
Refereed	Yes
Divisions	Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Publisher	Taylor & Francis
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