Investigating the influence of extracellular matrix and glycolytic metabolism on muscle stem cell migration on their native fibre environment

Butera, G., Collins-Hooper, H., Mitchell, R., Makarenkova, H. P., Lasagna, E. and Patel, K. (2015) Investigating the influence of extracellular matrix and glycolytic metabolism on muscle stem cell migration on their native fibre environment. Fibers, 3 (3). pp. 253-264. ISSN 2079-6439 doi: 10.3390/fib3030253

Abstract/Summary

The composition of the extracellular matrix (ECM) of skeletal muscle fibres is a unique environment that supports the regenerative capacity of satellite cells; the resident stem cell population. The impact of environment has great bearing on key properties permitting satellite cells to carry out tissue repair. In this study, we have investigated the influence of the ECM and glycolytic metabolism on satellite cell emergence and migration- two early processes required for muscle repair. Our results show that both influence the rate at which satellite cells emerge from the sub-basal lamina position and their rate of migration. These studies highlight the necessity of performing analysis of satellite behaviour on their native substrate and will inform on the production of artificial scaffolds intended for medical uses.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/40804
Identification Number/DOI	10.3390/fib3030253
Refereed	Yes
Divisions	Life Sciences > School of Biological Sciences > Biomedical Sciences
Publisher	MDPI
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