Reversal of a single base pair step controls guanine photo-oxidation by an intercalating Ru(II) dipyridophenazine complex

Keane, P. M., Poynton, F. E., Hall, J. P. ORCID: https://orcid.org/0000-0003-3716-4378, Sazanovich, I. V., Towrie, M., Gunnlaugsson, T., Quinn, S. J., Cardin, C. J. ORCID: https://orcid.org/0000-0002-2556-9995 and Kelly, J. M. (2015) Reversal of a single base pair step controls guanine photo-oxidation by an intercalating Ru(II) dipyridophenazine complex. Angewandte Chemie-International Edition, 54 (29). pp. 8364-8368. ISSN 1433-7851 doi: 10.1002/anie.201502608

Abstract/Summary

Small changes in DNA sequence can often have major biological effects. Here the rates and yields of guanine photo-oxidation by Λ [Ru(TAP)2(dppz)]2+ have been compared in 5′-{CCGGATCCGG}2 and 5′-{CCGGTACCGG}2 using ps/ns transient visible and time-resolved IR (TRIR) spectroscopy. The inefficiency of electron transfer in the TA sequence is consistent with the 5′-TA-3′ vs. 5′-AT-3′ binding preference predicted by X-ray crystallography. The TRIR spectra also reveal the differences in binding sites in the two oligonucleotides.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/40309
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Publisher	Wiley VCH
Publisher Statement	This is the peer reviewed version of the following article: 'Reversal of a single base pair step controls guanine photo-oxidation by an intercalating Ru(II) dipyridophenazine complex' which has been published in final form at DOI:10.1002/anie.201502608R2. This article may be used for non-commercial purposes in accordance With Wiley-VCH Terms and Conditions for self-archiving
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