Investigation of Petasis and Ugi reactions in series in an automated microreactor system

Heublein, N., Moore, J. S., Smith, C. D. ORCID: https://orcid.org/0000-0002-5911-5836 and Jensen, K. F. (2014) Investigation of Petasis and Ugi reactions in series in an automated microreactor system. RSC Advances, 4. pp. 363627-63631. ISSN 2046-2069 doi: 10.1039/c4ra13626h

Abstract/Summary

Petasis and Ugi reactions are used successively without intermediate purification, effectively accomplishing a six-component reaction. The examined reactions are transferred from traditional batch reactors to an automated continuous flow microreactor setup, where optimization and kinetic analyses are performed, proposed mechanisms evaluated, and rate-limiting steps determined.