Toll-like receptor agonist lipopeptides self-assemble into distinct nanostructures

Download

Preview

Text (Open Access) - Published Version
· Available under License Creative Commons Attribution.
· Please see our End User Agreement before downloading. | Preview

Available under license: Creative Commons Attribution

Advice

Please see our End User Agreement.

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

Tools

Lists

Hamley, I. ORCID: https://orcid.org/0000-0002-4549-0926, Kirkham, S., Dehsorkhi, A., Castelletto, V., Reza, M. and Ruokolainen, J. (2014) Toll-like receptor agonist lipopeptides self-assemble into distinct nanostructures. Chemical Communications, 50. pp. 15948-15951. ISSN 1359-7345 doi: 10.1039/c4cc07511k

Abstract/Summary

The self-assembled structure of toll-like receptor agonist lipopeptides containing the CSK4 peptide sequence is examined in aqueous solution. A remarkable dependence of morphology on the number of attached hexadecyl lipid chains is demonstrated, with spherical micelle structures for mono- and di-lipidated structures observed, but flexible wormlike micelles for the homologue containing three lipid chains. The distinct modes of assembly may have an important influence on the bioactivity of this class of lipopeptide.

Altmetric Badge

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/38485
Identification Number/DOI	10.1039/c4cc07511k
Refereed	Yes
Divisions	Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Publisher	The Royal Society of Chemistry
Download/View statistics	View download statistics for this item

Download Statistics

Downloads

Downloads per month over past year

Funded Project

Funders:	Engineering and Physical Sciences Research Council	The sponsoring bodies who contributed funding for the creation of this item. Example: NERC Example: The Royal Society of Chemistry A pick list of funders may appear as you type in the funder's name in full or as an acronym. Select a correct match to complete the field or type in a new entry in full. For new entries, the full name is preferred.
Projects:	A.Small-Angle Scattering Study of the Self-Assembly of Amyloid Peptide Fragments and Copolymers Funded by: Engineering and Physical Sciences Research Council (EP/G067538/1 - £149,644) Local Lead (PI): Ian Hamley Project Lead: Ian William Hamley 1 September 2009 - 30 April 2014 Nanostructured Polymeric Materials for Healthcare Funded by: Engineering and Physical Sciences Research Council (EP/L020599/1 - £1,185,824) Local Lead (PI): Ian Hamley Project Lead: Ian William Hamley 1 June 2014 - 31 May 2019	Click Add to select your project (received at Reading) from an autocomplete list.

Related URLs

Deposit Details

Date Deposited:	09 Dec 2014 11:40	Date item deposited into CentAUR
Last Modified:	24 Nov 2024 05:41	Date item last modified

University Staff: Request a correction | Centaur Editors: Update this record

Search Google Scholar