Long-term cultivation-independent microbial diversity analysis demonstrates that bacterial communities infecting the adult cystic fibrosis lung show stability and resilience.

Stressmann, F. A., Rogers, G. B., van der Gast, C. J., Marsh, P., Vermeer, L. S., Carroll, M. P., Hoffman, L., Daniels, T. W. V., Patel, N. ORCID: https://orcid.org/0000-0002-8600-0663, Forbes, B. and Bruce, K. D. (2012) Long-term cultivation-independent microbial diversity analysis demonstrates that bacterial communities infecting the adult cystic fibrosis lung show stability and resilience. Thorax, 67 (10). pp. 867-873. ISSN 1468-3296 doi: 10.1136/thoraxjnl-2011-200932

Abstract/Summary

Whilst not true in all cases, the microbial communities that chronically infect the airways of patients with CF can vary little over a year despite antibiotic perturbation. The species present tended to vary more between than within subjects, suggesting that each CF airway infection is unique, with relatively stable and resilient bacterial communities. The inverse relationship between community richness and disease severity is similar to findings reported in other mucosal infections.