Oligonucleotide compound and method for treating nidovirus infections

Sarepta Pharmaceuticals, The Scripps Research Institute (2014) Oligonucleotide compound and method for treating nidovirus infections. . (USOO8759307B2)

Abstract/Summary

A method and oligonucleotide compound for inhibiting replication of a nidovirus in virus-infected animal cells are disclosed. The compound (i) has a nuclease-resistant backbone, (ii) is capable of uptake by the infected cells, (iii) contains between 8-25 nucleotide bases, and (iv) has a sequence capable of disrupting base pairing between the transcriptional regulatory sequences in the 5′ leader region of the positive-strand viral genome and negative-strand 3′ subgenomic region. In practicing the method, infected cells are exposed to the compound in an amount effective to inhibit viral replication.

Additional Information	US Patent 8,759,307
Item Type	Patent
URI	https://reading-clone.eprints-hosting.org/id/eprint/37088
Divisions	Life Sciences > School of Biological Sciences > Biomedical Sciences
Additional Information	US Patent 8,759,307
Publisher	Google Patents
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