A genome-wide association meta-analysis identifies new childhood obesity loci

Bradfield, J. P., Taal, H. R., Timpson, N. J., Scherag, A., Lecoeur, C., Warrington, N. M., Hypponen, E., Holst, C., Valcarcel, B., Thiering, E., Salem, R. M., Schumacher, F. R., Cousminer, D. L., Sleiman, P. M. A., Zhao, J., Berkowitz, R. I., Vimaleswaran, K. S. ORCID: https://orcid.org/0000-0002-8485-8930, Jarick, I., Pennell, C. E., Evans, D. M., St Pourcain, B., Berry, D. J., Mook-Kanamori, D. O., Hofman, A., Rivadeneira, F., Uitterlinden, A. G., van Duijn, C. M., van der Valk, R. J. P., de Jongste, J. C., Postma, D. S., Boomsma, D. I., Gauderman, W. J., Hassanein, M. T., Lindgren, C. M., Mägi, R., Boreham, C. A. G., Neville, C. E., Moreno, L. A., Elliott, P., Pouta, A., Hartikainen, A.-L., Li, M., Raitakari, O., Lehtimäki, T., Eriksson, J. G., Palotie, A., Dallongeville, J., Das, S., Deloukas, P., McMahon, G., Ring, S. M., Kemp, J. P., Buxton, J. L., Blakemore, A. I. F., Bustamante, M., Guxens, M., Hirschhorn, J. N., Gillman, M. W., Kreiner-Møller, E., Bisgaard, H., Gilliland, F. D., Heinrich, J., Wheeler, E., Barroso, I., O'Rahilly, S., Meirhaeghe, A., Sørensen, T. I. A., Power, C., Palmer, L. J., Hinney, A., Widen, E., Farooqi, I. S., McCarthy, M. I., Froguel, P., Meyre, D., Hebebrand, J., Jarvelin, M.-R., Jaddoe, V. W. V., Smith, G. D., Hakonarson, H. and Grant, S. F. A. (2012) A genome-wide association meta-analysis identifies new childhood obesity loci. Nature Genetics, 44 (5). pp. 526-531. ISSN 1546-1718 doi: 10.1038/ng.2247

Abstract/Summary

Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10(-6) in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 × 10(-9); odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 × 10(-9); OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI(1).

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/34650
Item Type	Article
Refereed	Yes
Divisions	No Reading authors. Back catalogue items Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR) Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
Publisher	Nature Publishing Group
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