Compliant Multi-electrode Micro-channel Array for Recording Afferent Nerve Activity

Delivopoulos, E. ORCID: https://orcid.org/0000-0001-6156-1133, Chew, D., Minev, I., Fawcett, J. and Lacour, S. P. (2012) Compliant Multi-electrode Micro-channel Array for Recording Afferent Nerve Activity. In: Stett, A. and Zeck, G. (eds.) Proceedings, 8th International Meeting on Substrate-Integrated Microelectrode Arrays. NMI Natural and Medical Sciences Institute at the University of Tuebingen, Reutlingen, Germany, pp. 357-360.

Abstract/Summary

We have fabricated a compliant neural interface to record afferent nerve activity. Stretchable gold electrodes were evaporated on a polydimethylsiloxane (PDMS) substrate and were encapsulated using photo-patternable PDMS. The built-in microstructure of the gold film on PDMS allows the electrodes to twist and flex repeatedly, without loss of electrical conductivity. PDMS microchannels (5mm long, 100μm wide, 100μm deep) were then plasma bonded irreversibly on top of the electrode array to define five parallel-conduit implants. The soft gold microelectrodes have a low impedance of ~200kΩ at the 1kHz frequency range. Teased nerves from the L6 dorsal root of an anaesthetized Sprague Dawley rat were threaded through the microchannels. Acute tripolar recordings of cutaneous activity are demonstrated, from multiple nerve rootlets simultaneously. Confinement of the axons within narrow microchannels allows for reliable recordings of low amplitude afferents. This electrode technology promises exciting applications in neuroprosthetic devices including bladder fullness monitors and peripheral nervous system implants.