Theory and generalization of Monte Carlo models of the BOLD signal source

Martindale, J., Kennerley, A. J., Johnston, D., Zheng, Y. ORCID: https://orcid.org/0000-0001-7472-6427 and Mayhew, J. E. (2008) Theory and generalization of Monte Carlo models of the BOLD signal source. Magnetic Resonance in Medicine, 59 (3). pp. 607-618. ISSN 1522-2594 doi: 10.1002/mrm.21512

Abstract/Summary

The dependency of the blood oxygenation level dependent (BOLD) signal on underlying hemodynamics is not well understood. Building a forward biophysical model of this relationship is important for the quantitative estimation of the hemodynamic changes and neural activity underlying functional magnetic resonance imaging (fMRI) signals. We have developed a general model of the BOLD signal which can model both intra- and extravascular signals for an arbitrary tissue model across a wide range of imaging parameters. The model of the BOLD signal was instantiated as a look-up-table (LuT), and was verified against concurrent fMRI and optical imaging measurements of activation induced hemodynamics. Magn Reson Med, 2008. © 2008 Wiley-Liss, Inc.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/33482
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Biological Sciences > Department of Bio-Engineering
Uncontrolled Keywords	Monte Carlo simulations; biophysical model; BOLD; hemodynamics; fMRI
Publisher	Wiley
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