Memory versus naive T-cell migration

Lewis, M., Tarlton, J. F. and Cose, S. (2008) Memory versus naive T-cell migration. Immunology & Cell biology, 86 (3). pp. 226-231. ISSN 1440-1711 doi: 10.1038/sj.icb.7100132

Abstract/Summary

Our established understanding of lymphocyte migration suggests that naive and memory T cells travel throughout the body via divergent pathways; naive T cells circulate between blood and lymph whereas memory T cells additionally migrate through non-lymphoid organs. Evidence is now gradually emerging which suggests such disparate pathways between naive and memory T cells may not strictly be true, and that naive T cells gain access to the non-lymphoid environment in numbers approaching that of memory T cells. We discuss here the evidence for naive T-cell traffic into the non-lymphoid environment, compare and contrast this movement with what is known of memory T cells, and finally discuss the functional importance of why naive T cells might access the parenchymal tissues.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/33298
Identification Number/DOI	10.1038/sj.icb.7100132
Refereed	Yes
Divisions	No Reading authors. Back catalogue items Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Food Microbial Sciences Research Group
Publisher	Nature Publishing Group
Download/View statistics	View download statistics for this item