Collagen stimulating effect of peptide amphiphile C16−KTTKS on human fibroblasts

Jones, R. R., Castelletto, V., Connon, C. J. and Hamley, I. W. ORCID: https://orcid.org/0000-0002-4549-0926 (2013) Collagen stimulating effect of peptide amphiphile C16−KTTKS on human fibroblasts. Molecular Pharmaceutics, 10 (3). pp. 1063-1069. ISSN 1543-8392 doi: 10.1021/mp300549d

Abstract/Summary

The collagen production of human dermal and corneal fibroblasts in contact with solutions of the peptide amphiphile (PA) C16−KTTKS is investigated and related to its self-assembly into nanotape structures. This PA is used in antiwrinkle cosmeceutical applications (trade name Matrixyl). We prove that C16−KTTKS stimulates collagen production in a concentration-dependent manner close to the critical aggregation concentration determined from pyrene fluorescence spectroscopy. This suggests that self-assembly and the stimulation of collagen production are inter-related.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/32307
Item Type	Article
Refereed	Yes
Divisions	Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Uncontrolled Keywords	peptide amphiphile, Matrixyl, collagen, fibroblasts, skincare
Publisher	American Chemical Society
Download/View statistics	View download statistics for this item