Direct observation of membrane insertion by enveloped virus matrix proteins by phosphate displacement

Neuman, B. W., Kiss, G., Al-Mulla, H. M. N., Dokland, T., Buchmeier, M. J., Weikl, T. and Schley, D. (2013) Direct observation of membrane insertion by enveloped virus matrix proteins by phosphate displacement. PLoS ONE, 8 (2). e57916. ISSN 1932-6203

Abstract/Summary

Enveloped virus release is driven by poorly understood proteins that are functional analogs of the coat protein assemblies that mediate intracellular vesicle trafficking. We used differential electron density mapping to detect membrane integration by membrane-bending proteins from five virus families. This demonstrates that virus matrix proteins replace an unexpectedly large portion of the lipid content of the inner membrane face, a generalized feature likely to play a role in reshaping cellular membranes.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/31516
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Biological Sciences > Biomedical Sciences Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) > Electron Microscopy Laboratory (CAF)
Publisher	Public Library of Science
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