Asymmetric synthesis of peptides

Laurence M. Harwood / Ran Yan (2012) Asymmetric synthesis of peptides. US 2012/0190816 A9. doi: US 2012/0190816 A9

Abstract/Summary

The present invention provides a process comprising substitution of an acceptor molecule comprising a group -XC(O)- wherein X is O, S or NR8, where R8 is C1-6 alkyl, C6-12 aryl or hydrogen, with a nucleophile, wherein the acceptor molecule is cyclised such that said nucleophilic substitution at -XC (O)- occurs without racemisation. This process has particular application for the production of a peptide by extension from the activated carboxy-terminus of an acyl amino acid residue without epimerisation.

Item Type	Patent
URI	https://reading-clone.eprints-hosting.org/id/eprint/31416
Identification Number/DOI	US 2012/0190816 A9
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
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