Gene-nutrient interactions on the phosphoenolpyruvate carboxykinase influence insulin sensitivity in metabolic syndrome subjects

Perez-Martinez , P., Garcia-Rios , A., Delgado-Lista , J., Gjelstad, I. M. F., Gibney, J., Kieć-Wilk , B., Camargo, A., Helal , O., Karlström , B., Blaak , E. E., Hall, W., Risérus , U., Dembińska-Kieć , A., Defoort , C., Saris, W. H. M., Lovegrove, J. A. ORCID: https://orcid.org/0000-0001-7633-9455, Drevon, C. A., Roche, H. M. and Lopez-Miranda , J. (2013) Gene-nutrient interactions on the phosphoenolpyruvate carboxykinase influence insulin sensitivity in metabolic syndrome subjects. Clinical Nutrition, 32 (4). pp. 630-635. ISSN 0261-5614 doi: 10.1016/j.clnu.2012.10.003

Abstract/Summary

Genetic background may interact with habitual dietary fat composition, and affect development of the metabolic syndrome (MetS). The phosphoenolpyruvate carboxykinase gene (PCK1) plays a significant role regulating glucose metabolism, and fatty acids are key metabolic regulators, which interact with transcription factors and influence glucose metabolism. We explored genetic variability at the PCK1 gene locus in relation to degree of insulin resistance and plasma fatty acid levels in MetS subjects. Moreover, we analyzed the PCK1 gene expression in the adipose tissue of a subgroup of MetS subjects according to the PCK1 genetic variants.