Water-soluble tripeptide Aβ (9−11) forms amyloid-Like fibrils and exhibits neurotoxicity

Naskar, J., Drew, M., Deb, I., Das, S. and Banerjee, A. (2008) Water-soluble tripeptide Aβ (9−11) forms amyloid-Like fibrils and exhibits neurotoxicity. Organic Letters, 10 (13). pp. 2625-2628. ISSN 1523-7060 doi: 10.1021/ol8007217

Abstract/Summary

A water-soluble, hydrophilic tripeptide GYE, having sequence identity with the N-terminal segment of amyloid peptides A�(9-11), upon selfassociation exhibits amyloid-like fibrils and significant neurotoxicity towards the Neuro2A cell line. However, the tripeptides GFE and GWE, in which the centrally located tyrosine residue has been replaced by phenylalanine or tryptophan, fail to show amyloidogenic behavior and exhibit little or no neurotoxicity.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/31178
Identification Number/DOI	10.1021/ol8007217
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Publisher	The American Chemical Society
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