Do variations in substitution rates and male mutation bias correlate with life-history traits? A study of 32 mammalian genomes

Wilson Sayres, M. A., Venditti, C. ORCID: https://orcid.org/0000-0002-6776-2355, Pagel, M. ORCID: https://orcid.org/0000-0001-7287-8865 and Makova, K. D. (2011) Do variations in substitution rates and male mutation bias correlate with life-history traits? A study of 32 mammalian genomes. Evolution, 65 (10). pp. 2800-2815. ISSN 1558-5646 doi: 10.1111/j.1558-5646.2011.01337.x

Abstract/Summary

Life-history traits vary substantially across species, and have been demonstrated to affect substitution rates. We compute genomewide, branch-specific estimates of male mutation bias (the ratio of male-to-female mutation rates) across 32 mammalian genomes and study how these vary with life-history traits (generation time, metabolic rate, and sperm competition). We also investigate the influence of life-history traits on substitution rates at unconstrained sites across a wide phylogenetic range. We observe that increased generation time is the strongest predictor of variation in both substitution rates (for which it is a negative predictor) and male mutation bias (for which it is a positive predictor). Although less significant, we also observe that estimates of metabolic rate, reflecting replication-independent DNA damage and repair mechanisms, correlate negatively with autosomal substitution rates, and positively with male mutation bias. Finally, in contrast to expectations, we find no significant correlation between sperm competition and either autosomal substitution rates or male mutation bias. Our results support the important but frequently opposite effects of some, but not all, life history traits on substitution rates. KEY WORDS: Generation time, genome evolution, metabolic rate, sperm competition.