In vitro antioxidant activity and antigenotoxicity of 5-n-alkylresorcinols

Parikka, K., Rowland, I. R., Welch, R. W. and Wähälä, K. (2006) In vitro antioxidant activity and antigenotoxicity of 5-n-alkylresorcinols. Journal of Agricultural and Food Chemistry, 54 (5). pp. 1646-1650. ISSN 0021-8561 doi: 10.1021/jf052486e

Abstract/Summary

Incubation with 5-n-alkylresorcinols (chain lengths C15:0, C17:0, C19:0, C21:0, and C23:0) increased the self-protection capacity of HT29 human colon cancer cells against DNA damage induced by hydrogen peroxide and genotoxic fecal water samples using comet assay (single-cell gel electrophoresis assay). The alkylresorcinols did not exert potent antioxidant activity in the FRAP (ferric reduction ability of plasma) and DPPH (2,2-diphenyl-1-picrylhydrazyl) radical assays. However they were able to significantly inhibit copper-mediated oxidation of human LDL (low-density lipoprotein) in vitro, and pentadecylresorcinol at 25 micromol/L increased lag time by 65 min. The results show that alkylresorcinols have antigenotoxic and antioxidant activity under in vitro conditions.