The impact of the catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion

Miller, R., Jackson, K. G. ORCID: https://orcid.org/0000-0002-0070-3203, Dadd, T., Mayes, A.E., Brown, L., Lovegrove, J. A. ORCID: https://orcid.org/0000-0001-7633-9455 and Minihane, A. M. (2012) The impact of the catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion. Molecular Nutrition & Food Research, 56 (6). pp. 966-975. ISSN 1613-4133 doi: 10.1002/mnfr.201100726

Abstract/Summary

SCOPE: Evidence for the benefits of green tea catechins on vascular function is inconsistent, with genotype potentially contributing to the heterogeneity in response. Here, the impact of the catechol-O-methyltransferase (COMT) genotype on vascular function and blood pressure (BP) after green tea extract ingestion are reported. METHODS AND RESULTS: Fifty subjects (n = 25 of the proposed low-activity [AA] and of the high-activity [GG] COMT rs4680 genotype), completed a randomized, double-blind, crossover study. Peripheral arterial tonometry, digital volume pulse (DVP), and BP were assessed at baseline and 90 min after 1.06 g of green tea extract or placebo. A 5.5 h and subsequent 18.5 h urine collection was performed to assess green tea catechin excretion. A genotype × treatment interaction was observed for DVP reflection index (p = 0.014), with green tea extract in the AA COMT group attenuating the increase observed with placebo. A tendency for a greater increase in diastolic BP was evident at 90 min after the green tea extract compared to placebo (p = 0.07). A genotypic effect was observed for urinary methylated epigallocatechin during the first 5.5 h, with the GG COMT group demonstrating a greater concentration (p = 0.049). CONCLUSION: Differences in small vessel tone according to COMT genotype were evident after acute green tea extract.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/27765
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
Uncontrolled Keywords	Blood pressure;Catechol-O-methyltransferase;Endothelial function;Flavonoids;Green tea
Publisher	Wiley
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