Assembling novel protein folds from super-secondary structural fragments

Jones, D. T. and McGuffin, L. J. ORCID: https://orcid.org/0000-0003-4501-4767 (2003) Assembling novel protein folds from super-secondary structural fragments. Proteins: Structure, Function, and Genetics, 53 (S6). pp. 480-485. ISSN 0887-3585 doi: 10.1002/prot.10542

Abstract/Summary

The results of applying a fragment-based protein tertiary structure prediction method to the prediction of 14 CASP5 target domains are described. The method is based on the assembly of supersecondary structural fragments taken from highly resolved protein structures using a simulated annealing algorithm. A number of good predictions for proteins with novel folds were produced, although not always as the first model. For two fold recognition targets, FRAGFOLD produced the most accurate model in both cases, despite the fact that the predictions were not based on a template structure. Although clear progress has been made in improving FRAGFOLD since CASP4, the ranking of final models still seems to be the main problem that needs to be addressed before the next CASP experiment

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/27434
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Biological Sciences > Biomedical Sciences No Reading authors. Back catalogue items
Publisher	Wiley
Download/View statistics	View download statistics for this item