Molybdate and tungstate transfer by rat ileum competitive inhibition by sulphate

Cardin, C. J. ORCID: https://orcid.org/0000-0002-2556-9995 and Mason, J. (1976) Molybdate and tungstate transfer by rat ileum competitive inhibition by sulphate. Biochimica et Biophysica Acta (BBA) - Biomembranes, 455 (3). pp. 937-946. ISSN 0005-2736 doi: 10.1016/0005-2736(76)90062-6

Abstract/Summary

For both MoO42− and WO42− the maximum rate of uptake by the small intestine of the rat (studied in vitro using the everted sac technique) occurs in the lower ileum. Kinetic constants, derived by a least squares procedure, are compared with those previously obtained for SO42− transport. For both and , , with only small differences between sacs IV and V. Mutual inhibition of MoO42− and WO42− transport and inhibition of both by SO42− are competitive processes. This is shown by the generally good agreement between values and derived values and by V values in the presence and absence of the inhibiting species. The three ions SO42−, MoO42− and WO42− are probably transferred across the intestine by a common carrier system. Implications for the sulphate-molybdenum interaction in molybdosis are discussed.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/23890
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Publisher	Elsevier
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