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Adaptive designs for Phase I dose-finding studies

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Zhou, Y. (2010) Adaptive designs for Phase I dose-finding studies. Fundamental & Clinical Pharmacology, 24 (2). pp. 129-138. ISSN 0767-3981 doi: 10.1111/j.1472-8206.2009.00746.x

Abstract/Summary

Improving methodology for Phase I dose-finding studies is currently of great interest in pharmaceutical and medical research. This article discusses the current atmosphere and attitude towards adaptive designs and focuses on the influence of Bayesian approaches.

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Item Type Article
URI https://reading-clone.eprints-hosting.org/id/eprint/17763
Identification Number/DOI 10.1111/j.1472-8206.2009.00746.x
Refereed Yes
Divisions Science > School of Mathematical, Physical and Computational Sciences > Department of Mathematics and Statistics > Applied Statistics
Uncontrolled Keywords adaptive designs; Bayesian approaches; dose-finding studies continual reassessment method; i/ii clinical-trials; Bayesian decision procedures; healthy-volunteers; down designs; escalation; agent; toxicity; efficacy; outcomes
Publisher Wiley
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