Effects of resistant starch type III polymorphs on human colon microbiota and short chain fatty acids in human gut models

Lesmes, U., Beards, E.J., Gibson, G.R. ORCID: https://orcid.org/0000-0002-0566-0476, Tuohy, K.M. and Shimoni, E. (2008) Effects of resistant starch type III polymorphs on human colon microbiota and short chain fatty acids in human gut models. Journal of Agricultural and Food Chemistry, 56 (13). pp. 5415-5421. ISSN 0021-8561 doi: 10.1021/jf800284d

Abstract/Summary

This study probed the possible effects of type III resistant starch (RS) crystalline polymorphism on RS fermentability by human gut microbiota and the short chain fatty acids production in vitro. Human fecal pH-controlled batch cultures showed RS induces an ecological shift in the colonic microbiota with polymorph B inducing Bifidobacterium spp. and polymorph A inducing Atopobium spp. Interestingly, polymorph B also induced higher butyrate production to levels of 0.79 mM. In addition, human gut simulation demonstrated that polymorph B promotes the growth of bifidobacteria in the proximal part of the colon and double their relative proportion in the microbiota in the distal colon. These findings suggest that RS polymorph B may promote large bowel health. While the findings are limited by study constraints, they do raise the possibility of using different thermal processing to delineate differences in the prebiotic capabilities of RS, especially its butryrogenicity in the human colon.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/13216
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
Uncontrolled Keywords	resistant starch, prebiotics, butyrate, bifidobacteria, human colon microbiota , IN-SITU HYBRIDIZATION, X-RAY-SCATTERING, OLIGONUCLEOTIDE PROBES, BUTYRATE FORMATION, HUMAN FECES, BACTERIA, FERMENTATION, METABOLISM, RATS, RETROGRADATION
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