Genicular artery embolisation in patients with osteoarthritis of the knee (GENESIS) using permanent microspheres: long-term results

Little, M. W., O'Grady, A., Briggs, J., Gibson, M., Speirs, A., Al-Rekabi, A., Yoong, P., Ariyanayagam, T., Davies, N., Tayton, E., Tavares, S., MacGill, S., McLaren, C. and Harrison, R. ORCID: https://orcid.org/0000-0003-3674-9622 (2024) Genicular artery embolisation in patients with osteoarthritis of the knee (GENESIS) using permanent microspheres: long-term results. Cardiovascular and Interventional Radiology. ISSN 1432-086X doi: 10.1007/s00270-024-03752-7

Abstract/Summary

Purpose: To report the 2-year follow-up of patients with mild-to-moderate knee osteoarthritis (OA) treated with genicular artery embolisation (GAE) as part of the GENESIS study. Materials and methods: Forty-six patients, median age = 60 (45-83) underwent GAE using permanent microspheres (100-300 μm). Technical success was defined as embolisation of the targeted genicular arteries. Knee Injury and Osteoarthritis Outcome Score (KOOS) and Visual Analogue Scale (VAS) (0-100 mm) were recorded at baseline, 6 weeks, 3 months, 1, 2 years. Contrast-enhanced MRI knee scans were acquired at baseline and 1 year, and evaluated with the Whole-Organ Magnetic Resonance Imaging Score (WORMS). Functional MRI brain imaging and psychometric assessments were undertaken to investigate correlation between neuropsychological phenotypes and clinical outcome. Adverse events were recorded prospectively. Results: Technical success was achieved in forty patients (87%). Mean VAS improved from 58.63 (SD = 20.57, 95% CI 52.7-65.5) at baselines to 37.7 at 2-years (SD = 26.3, 95% CI 27.0-47.5). Whole and subgroup KOOS were significantly improved at each timepoint with associated reductions in analgesia usage. WORMS analysis demonstrated significant reduction in synovitis (p < 0.05) with no cases of osteonecrosis. Self-limiting skin discolouration occurred in four patients. A self-limiting groin haematoma and single case of deep-vein thrombosis due to immobilisation were also recorded. Nine patients subsequently underwent knee arthroplasty with no additional operational complexities identified. Neuropsychometric assessment elucidated a correlation between baseline catastrophising and greater reduction in pain post GAE. Conclusion: GAE is a safe intervention for mild-moderate knee osteoarthritis, with sustained efficacy at 2 years. These results are promising and justify ongoing controlled trials.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/116825
Identification Number/DOI	10.1007/s00270-024-03752-7
Refereed	Yes
Divisions	Interdisciplinary Research Centres (IDRCs) > Centre for Integrative Neuroscience and Neurodynamics (CINN) Interdisciplinary centres and themes > Pain Research
Publisher	Springer
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