Block copolymers of ethylene oxide and phenyl glycidyl ether: micellization, gelation, and drug solubilization

Taboada, P., Velasquez, G., Barbosa, S., Castelletto, V., Nixon, S.K., Yang, Z., Heatley, F., Hamley, I.W. ORCID: https://orcid.org/0000-0002-4549-0926, Ashford, M., Mosquera, V., Attwood, D. and Booth, C. (2005) Block copolymers of ethylene oxide and phenyl glycidyl ether: micellization, gelation, and drug solubilization. Langmuir, 21 (12). pp. 5263-5271. ISSN 0743-7463 doi: 10.1021/la0503808

Abstract/Summary

Three triblock copolymers of ethylene oxide and phenyl glycidyl ether, type E(m)G(n)E(m), where G = OCH2-CH(CH2OC6H5) and E = OCH2CH2, were synthesized and characterized by gel-permeation chromatography, matrix-assisted laser desorption ionization time-of-flight mass spectrometry, and NMR spectroscopy. Their association properties in aqueous solution were investigated by surface tensiometry and light scattering, yielding values of the critical micelle concentration (cmc), the hydrodynamic radius, and the association number. Gel boundaries in concentrated micellar solution were investigated by tube inversion, and for one copolymer, the temperature and frequency dependence of the dynamic moduli served to confirm and extend the phase diagram and to highlight gel properties. Small-angle X-ray scattering was used to investigate gel structure. The overall aim of the work was to define a block copolymer micellar system with better solubilization capacity for poorly soluble aromatic drugs than had been achieved so far by use of block copoly(oxyalkylene)s. Judged by the solubilization of griseofulvin in aqueous solutions of the E(m)G(n)E(m) copolymers, this aim was achieved.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/11650
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Uncontrolled Keywords	AQUEOUS MICELLAR-SOLUTIONS, LENGTHY OXYETHYLENE BLOCKS, NUCLEAR-MAGNETIC-RESONANCE, STYRENE OXIDE, 1,2-BUTYLENE OXIDE, TRIBLOCK COPOLYMER, ASSOCIATION PROPERTIES, DIBLOCK COPOLYMER, GLASS-TRANSITION, PHASE-BEHAVIOR
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