Saturated fat and cardiovascular disease: importance of inter-individual variation in the response of serum low-density lipoprotein cholesterol

Griffin, B. A. and Lovegrove, J. A. ORCID: https://orcid.org/0000-0001-7633-9455 (2024) Saturated fat and cardiovascular disease: importance of inter-individual variation in the response of serum low-density lipoprotein cholesterol. Proceedings of the Nutrition Society. ISSN 1475-2719 doi: 10.1017/S0029665124000107

Abstract/Summary

The aim of this review is to provide an overview of the history in support of the role of dietary saturated fatty acids (SFA) in the development of cardiovascular disease (CVD), and the controversy and consensus for the evidence in support of guidelines to remove and replace SFA with unsaturated fatty acids. The review will also examine the existence, origins, and implications for CVD risk of variability in serum LDL-cholesterol in response to these guidelines. While the quality of supporting evidence for the efficacy of restricting SFA on CVD risk has attracted controversy, this has helped to increase understanding of the inter-relationships between SFA, LDL-cholesterol and CVD, and reinforce confidence in this dietary recommendation. Nevertheless, there is significant inter-individual variation in serum LDL-C in response to this dietary change. The origins of this variation are multi-factorial and involve both dietary and metabolic traits. If serum biomarkers of more complex metabolic traits underlying LDL-responsiveness can be identified, this would have major implications for the targeting of these dietary guidelines to LDL-responders, to maximise the benefit to their cardiovascular health.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/115198
Identification Number/DOI	10.1017/S0029665124000107
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
Uncontrolled Keywords	cardiovascular disease, Saturated fatty acids, serum LDL-cholesterol
Publisher	Cambridge University Press
Download/View statistics	View download statistics for this item