On the mucoadhesive properties of synthetic and natural polyampholytes

Fu, M., Filippov, S. K., Williams, A. C. ORCID: https://orcid.org/0000-0003-3654-7916 and Khutoryanskiy, V. V. ORCID: https://orcid.org/0000-0002-7221-2630 (2024) On the mucoadhesive properties of synthetic and natural polyampholytes. Journal of Colloid and Interface Science, 659. pp. 849-858. ISSN 0021-9797 doi: 10.1016/j.jcis.2023.12.176

Abstract/Summary

Hypothesis The mucoadhesive characteristics of amphoteric polymers (also known as polyampholytes) can vary and are influenced by factors such as the solution's pH and its relative position against their isoelectric point (pHIEP). Whilst the literature contains numerous reports on mucoadhesive properties of either cationic or anionic polymers, very little is known about these characteristics for polyampholytes Experiments Here, two amphoteric polymers were synthesized by reaction of linear polyethylene imine (l-PEI) with succinic or phthalic anhydride and their mucoadhesive properties were compared to bovine serum albumin (BSA), selected as a natural polyampholyte. Interactions between these polymers and porcine gastric mucin were studied using turbidimetric titration and isothermal titration calorimetry across a wide range of pHs. Model tablets were designed, coated with these polymers and tested to evaluate their adhesion to porcine gastric mucosa at different pHs. Moreover, a retention study using fluorescein isothiocyanate (FITC)-labelled polyampholytes deposited onto mucosal surfaces was also conducted Findings All these studies indicated the importance of solution pH and its relative position against pHIEP in the mucoadhesive properties of polyampholytes. Both synthetic and natural polyampholytes exhibited strong interactions with mucin and good mucoadhesive properties at pH < pHIEP.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/114696
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
Publisher	Elsevier
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