Advanced search

Robotic microfluidic imaging of blood stimulation- towards high-throughput portable measurement of haemostasis

Download
[thumbnail of Open Access]
Preview
Text (Open Access) - Published Version
· Available under License Creative Commons Attribution.
· Please see our End User Agreement before downloading. | Preview
Available under license: Creative Commons Attribution
Advice

Please see our End User Agreement.

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

Tools
Add to AnyAdd to TwitterAdd to FacebookAdd to LinkedinAdd to PinterestAdd to Email
Lists

Sarıyer, R. M. orcid id iconORCID: https://orcid.org/0000-0002-2155-653X, Gill, K., Needs, S. H. orcid id iconORCID: https://orcid.org/0000-0003-3407-9637, Hodge, D., Reis, N. M., Jones, C. I. orcid id iconORCID: https://orcid.org/0000-0001-7537-1509 and Edwards, A. D. orcid id iconORCID: https://orcid.org/0000-0003-2369-989X (2023) Robotic microfluidic imaging of blood stimulation- towards high-throughput portable measurement of haemostasis. British Journal of Pharmacy, 8 (2). ISSN 2058-8356 doi: 10.5920/bjpharm.1365

Abstract/Summary

Measuring blood and platelet function is vital for the development and use of drugs that combat cardiovascular disease, such as anti-platelet drugs and other medicines that reduce the risk of thrombosis. We propose combining mass-produced microfluidic devices with open-source robotic instrumentation to enable development of affordable and portable, yet high-throughput and high-performance haematological testing. A time- and distance-resolved fluid flow analysis by Raspberry Pi imaging integrated with controlled sample addition and illumination, enables simultaneous tracking of capillary rise in 120 individual capillaries within 5minutes. We showed that time-resolved microcapillary rise imaging permits blood function measurement by measuring thrombin-triggered activation of global haemostasis. Thrombin stimulation slowed vertical fluid velocity, consistent with a dynamic increase in viscosity. Microfluidic systems expand haematological testing towards high-efficiency, multi-parameter blood analysis necessary for understanding and improving cardiovascular health.

Altmetric Badge

Item Type Article
URI https://reading-clone.eprints-hosting.org/id/eprint/114623
Identification Number/DOI 10.5920/bjpharm.1365
Refereed Yes
Divisions Life Sciences > School of Biological Sciences > Biomedical Sciences
Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
Uncontrolled Keywords General Medicine
Publisher University of Huddersfield Press
Download/View statistics View download statistics for this item
Download Statistics

Downloads

Downloads per month over past year

Deposit Details

University Staff: Request a correction | Centaur Editors: Update this record

Search Google Scholar