A review on the use of prebiotics in ulcerative colitis

Kennedy, J. M. ORCID: https://orcid.org/0000-0001-9335-0808, De Silva, A., Walton, G. E. ORCID: https://orcid.org/0000-0001-5426-5635 and Gibson, G. R. ORCID: https://orcid.org/0000-0002-0566-0476 (2023) A review on the use of prebiotics in ulcerative colitis. Trends in Microbiology. ISSN 1878-4380 doi: 10.1016/j.tim.2023.11.007

Abstract/Summary

The gut microbiome in the inflammatory bowel disease, ulcerative colitis (UC), is different to that of healthy controls. Patients with UC have relative reductions in abundance of Firmicutes and Bifidobacterium in the colon, and an increase in sulfate-reducing bacteria. Prebiotics are dietary substrates which are selectively metabolised by the human colonic microbiota to confer health benefits to the host. This review explores our current understanding of the potential benefits of prebiotics on various clinical, biochemical, and microbiological endpoints in UC, including new perspectives gained from recent studies in the field. This review looks to the future and highlights the need for appropriately designed trials to explore this potentially exciting new avenue for the treatment of UC.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/114294
Identification Number/DOI	10.1016/j.tim.2023.11.007
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Food Microbial Sciences Research Group
Publisher	Cell Press
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