Striatal correlates of Bayesian beliefs in self-efficacy in adolescents and their relation to mood and autonomy: a pilot study

Romaniuk, L. ORCID: https://orcid.org/0000-0002-3823-8052, MacSweeney, N., Atkinson, K., Chan, S. W. Y. ORCID: https://orcid.org/0000-0003-4088-4528, Barbu, M. C., Lawrie, S. M. and Whalley, H. C. (2023) Striatal correlates of Bayesian beliefs in self-efficacy in adolescents and their relation to mood and autonomy: a pilot study. Cerebral Cortex Communications, 4 (4). tgad020. ISSN 2632-7376 doi: 10.1093/texcom/tgad020

Abstract/Summary

Major depressive disorder often originates in adolescence and is associated with long-term functional impairment. Mechanistically characterizing this heterogeneous illness could provide important leads for optimizing treatment. Importantly, reward learning is known to be disrupted in depression. In this pilot fMRI study of 21 adolescents (16–20 years), we assessed how reward network disruption impacts specifically on Bayesian belief representations of self-efficacy (SE-B) and their associated uncertainty (SE-U), using a modified instrumental learning task probing activation induced by the opportunity to choose, and an optimal Hierarchical Gaussian Filter computational model. SE-U engaged caudate, nucleus accumbens (NAcc), precuneus, posterior parietal and dorsolateral prefrontal cortex (P FWE < 0.005). Sparse partial least squares analysis identified SE-U striatal activation as associating with one’s sense of perceived choice and depressive symptoms, particularly anhedonia and negative feelings about oneself. As Bayesian uncertainty modulates belief flexibility and their capacity to steer future actions, this suggests that these striatal signals may be informative developmentally, longitudinally and in assessing response to treatment.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/114028
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Psychology and Clinical Language Sciences > Department of Psychology Life Sciences > School of Psychology and Clinical Language Sciences > Department of Clinical Language Sciences
Uncontrolled Keywords	General Medicine
Publisher	Oxford University Press (OUP)
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