A flexible solution to anion transport: powerful anionophores based on a cyclohexane scaffold

Cooper, J. A. ORCID: https://orcid.org/0000-0002-3981-9246, Street, S. T. G. and Davis, A. P. (2014) A flexible solution to anion transport: powerful anionophores based on a cyclohexane scaffold. Angewandte Chemie International Edition, 53 (22). pp. 5609-5613. ISSN 1433-7851 doi: 10.1002/anie.201311071

Abstract/Summary

Transmembrane anion carriers (anionophores) have potential for biological activity, including the treatment of channelopathies such as cystic fibrosis. A new family of anionophores has been synthesized, in which three thiourea groups are mounted on a cyclohexane-based scaffold. Though conceptually related to earlier polycyclic systems, these molecules are simpler and far more accessible. Preorganization is somewhat reduced compared to earlier systems, and anion affinities are correspondingly lower. However, transport activities set new records. This surprising performance suggests a role for controlled flexibility in the design of transmembrane anion carriers.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/113522
Item Type	Article
Refereed	Yes
Divisions	No Reading authors. Back catalogue items
Publisher	Wiley
Download/View statistics	View download statistics for this item