Keeping up with the kids: the value of co-production in the study of irritability in youth depression and its underlying neural circuitry

MacSweeney, N., Louvet, P., Zafar, S., Chan, S. W. Y. ORCID: https://orcid.org/0000-0003-4088-4528, Kwong, A. S. F., Lawrie, S. M., Romaniuk, L. and Whalley, H. C. (2023) Keeping up with the kids: the value of co-production in the study of irritability in youth depression and its underlying neural circuitry. Frontiers in Behavioral Neuroscience, 17. 1124940. ISSN 1662-5153 doi: 10.3389/fnbeh.2023.1124940

Abstract/Summary

Irritability is a core symptom of adolescent depression, characterized by an increased proneness to anger or frustration. Irritability in youth is associated with future mental health problems and impaired social functioning, suggesting that it may be an early indicator of emotion regulation difficulties. Adolescence is a period during which behavior is significantly impacted by one's environment. However, existing research on the neural basis of irritability typically use experimental paradigms that overlook the social context in which irritability occurs. Here, we bring together current findings on irritability in adolescent depression and the associated neurobiology and highlight directions for future research. Specifically, we emphasize the importance of co-produced research with young people as a means to improve the construct and ecological validity of research within the field. Ensuring that our research design and methodology accurately reflect to lives of young people today lays a strong foundation upon which to better understand adolescent depression and identify tractable targets for intervention.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/112605
Item Type	Article
Refereed	Yes
Divisions	Interdisciplinary centres and themes > Charlie Waller Institute
Uncontrolled Keywords	fMRI, adolescence, co-production, irritability, adolescent depression
Publisher	Frontiers
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